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List of Latest Keto Studies

  • An umbrella review of meta-analyses of randomized clinical trials (RCTs) published on May 25, 2023, investigated the health outcomes associated with ketogenic diets (KDs). The review included 17 meta-analyses comprising 68 RCTs. It found that there were statistically significant associations of KDs with reduced triglyceride levels, decreased seizure frequency, and increased low-density lipoprotein cholesterol (LDL-C). It also noted that in overweight or obese adults, very low-calorie ketogenic diets (VLCKDs) significantly improved anthropometric and cardiometabolic outcomes without worsening muscle mass, LDL-C, and total cholesterol. However, the evidence varied in quality, and there were calls for long-term clinical trials to understand the effects on cardiovascular events and mortality​1​​2​.

    Reference: BMC Medicine

  • A study from UC Davis Health, referenced in a Q&A with molecular exercise physiologist Keith Baar, found that a keto diet in older animals prevents loss of muscle mass due to age and improves muscle function. The ketogenic diet was shown to maintain muscle strength and endurance into old age, as well as muscle mass. Additionally, the keto diet's impact on brain health was highlighted, noting its traditional use in treating epilepsy and potential for treating age-related neurological decline and possibly Alzheimer's disease. The study did not find substantial benefits for athletes' muscle function​3​.

    Reference: UC Davis Health

  • Research presented on March 5, 2023, at the American College of Cardiology’s Annual Scientific Session suggests that a keto-like diet may be linked to a higher risk of heart disease and cardiac events. The study found that a diet low in carbohydrates and high in fat was associated with increased levels of LDL cholesterol and a twofold heightened risk of cardiovascular events. The study analyzed data from the UK Biobank and found that after an average of 11.8 years of follow-up, participants on a keto-like diet had more than double the risk of having several major cardiovascular events compared to those on a standard diet​4​.

    Reference: American College of Cardiology

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